The Novavax vaccine and how it could be an alternative to mRNA vaccines
As the global vaccination effort against COVID-19 continues, it has become evident that vaccines are one of our most potent tools in combating the pandemic. The mRNA vaccines have proven highly effective and safe for most individuals. However, like all medical interventions, they are not without side effects. Some people have experienced adverse reactions to these vaccines, prompting questions about alternative options. Novavax, a protein subunit vaccine, has emerged as a potential alternative for those affected.
Understanding mRNA vaccine adverse reactions
Before delving into the potential benefits of Novavax as an alternative, it’s crucial to understand why some individuals experience adverse reactions to mRNA vaccines. Adverse reactions to vaccines, in general, may range from mild to severe, but most of the side effects reported with mRNA vaccines have been mild and transient, including pain at the injection site, fatigue, headache, and mild fever. However, some individuals have reported more pronounced side effects, such as severe allergic reactions (anaphylaxis) and myocarditis (inflammation of the heart muscle). These cases have raised concerns and prompted individuals with allergies or previous adverse reactions to vaccines to seek alternative vaccination options.
A protein subunit vaccine
Novavax, also known as NVX-CoV2373, represents an alternative approach to vaccination. Instead of using messenger RNA, Novavax employs a protein subunit strategy. Here’s how it differs:
Antigen source
The Novavax vaccine relies on a small piece of the spike protein found on the surface of the SARS-CoV-2 virus as its antigen. This spike protein is produced in a lab, purified, and used to stimulate an immune response. In contrast, mRNA vaccines provide genetic instructions for cells to produce a synthetic spike protein.
Storage and distribution
One significant advantage of Novavax is its storage and distribution requirements. While mRNA vaccines require ultra-cold storage, Novavax is stored at standard refrigerator temperatures, making it more accessible in a wider range of settings.
